Fixed drug eruption (FDE) is a common entity encountered in our day-to-day clinical practice.It is a T-cell-dependent pathway with induction of interferon-gamma-producing CD8+ T-cells in the dermis and epidermis.It is not deroyal finger spring just a drug that causes a fixed eruption but has also been described with food known as fixed food eruption and also with other agents.
The article describes the buffalo bills big chain necklace common causes and pathomechanism of FDE.